Santacruz is a section of the municipality of Mumbai. It is also the name of the Santacruz (railway station) on the Mumbai Suburban Railway. The Domestic Terminal of the Airport of Mumbai and one campus of the University of Mumbai are in Santacruz. Santacruz is surrounded by Vile Parle in north, Khar in south, Juhu in west and Kurla in east. It is broadly divided in two areas: Santa Cruz (East) and Santa Cruz (West) by the Mumbai Suburban Railway line. The Milan subway and Khar subway connect the two areas, passing under the rail line.

Santacruz has become one of the popular residential areas in Mumbai because of leading Real Estate Developers of Mumbai like RNA Corp. has launched new Residential properties, Apartment and Flats in Santacruz at affordable price with all modern amenities.